| Identification | Back Directory | [Name]
UNC2170 Maleate | [CAS]
1648707-58-7 | [Synonyms]
UNC-2170
UNC-2170 HCl
UNC2170 Maleate
UNC2170 trifluoroacetate
3-Bromo-N-(3-(tert-butylamino)propyl)benzamide
Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]- | [Molecular Formula]
C14H21BrN2O | [MDL Number]
MFCD29770818 | [MOL File]
1648707-58-7.mol | [Molecular Weight]
313.23 |
| Chemical Properties | Back Directory | [Boiling point ]
419.6±30.0 °C(Predicted) | [density ]
1.233±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml). | [form ]
solid | [pka]
14.63±0.46(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1 | [storage]
4°C, protect from light | [References]
1) Perfetti?et al.?(2015),?Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol.,?10?1072 |
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Lynnchem
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86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
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