| Identification | Back Directory | [Name]
YAP-TEAD Inhibitor 1 | [CAS]
1659305-78-8 | [Synonyms]
YAP-TEAD-IN-1
YAP-TEAD Inhibitor 1
L-α-Glutamine, N-acetyl-L-valyl-L-prolyl-3-chloro-L-phenylalanyl-L-homocysteinyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-prolyl-L-alanyl-L-seryl-L-phenylalanyl-L-cysteinyl-L-lysyl-L-prolyl-L-prolyl-, cyclic (4→13)-disulfide | [Molecular Formula]
C93H144ClN23O21S2 | [MDL Number]
MFCD32706886 | [MOL File]
1659305-78-8.mol | [Molecular Weight]
2019.86 |
| Hazard Information | Back Directory | [Biological Activity]
YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2]. | [storage]
Store at -20°C | [References]
[1] Zhang Z, et al. ACS Med Chem Lett. 2014, 5(9):993-998.
[2] Zhou Z, et al. FASEB J. 2015, 29(2):724-732. |
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