| Identification | Back Directory | [Name]
1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one | [CAS]
16616-39-0 | [Synonyms]
MLS000532223
1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one
2-Propyn-1-one, 1-(3-nitrophenyl)-3-phenyl- | [Molecular Formula]
C15H9NO3 | [MDL Number]
MFCD00560016 | [MOL File]
16616-39-0.mol | [Molecular Weight]
251.24 |
| Chemical Properties | Back Directory | [Melting point ]
120-121 °C | [Boiling point ]
419.6±47.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
RT (des.) | [solubility ]
Soluble in DMSO (up to 20 mg/ml). | [form ]
solid | [color ]
Beige | [Stability:]
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
MLS-532223 (16616-39-0) is a high-affinity selective inhibitor of Rho family GTPases (EC50=10 μM). It inhibits EGF-stimulated Rac1 activation (3-10 μM). Cell permeable. | [Definition]
ChEBI: 1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one is an aromatic compound. | [References]
1) Surviladze et al. (2010), Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay; J. Biomol. Screening, 15 10 |
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