| Identification | Back Directory | [Name]
BMS-8 | [CAS]
1675201-90-7 | [Synonyms]
BMS-8
2-Piperidinecarboxylic acid, 1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]- | [Molecular Formula]
C27H28BrNO3 | [MDL Number]
MFCD31714164 | [MOL File]
1675201-90-7.mol | [Molecular Weight]
494.42 |
| Chemical Properties | Back Directory | [Boiling point ]
616.9±55.0 °C(Predicted) | [density ]
1.334±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Methanol: slightly soluble | [form ]
A crystalline solid | [pka]
2.35±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
BMS-8 is a small molecule inhibitor of the protein-protein interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.1 | [Uses]
BMS-8 is inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization. |
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| Company Name: |
InvivoChem Gold
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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