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ChemicalBook--->CAS DataBase List--->1676893-24-5

1676893-24-5

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1676893-24-5 Structure

1676893-24-5 Structure
IdentificationBack Directory
[Name]

NSC781406
[CAS]

1676893-24-5
[Synonyms]

NSC781406
NSC-781406;NSC 781406
NSC781406;NSC-781406;NSC 781406
Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-
[Molecular Formula]

C29H27F2N5O5S2
[MOL File]

1676893-24-5.mol
[Molecular Weight]

627.68
Chemical PropertiesBack Directory
[Boiling point ]

775.1±70.0 °C(Predicted)
[density ]

1.52±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
[form ]

A solid
[pka]

6.23±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.
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