| Chemical Properties | Back Directory | [Boiling point ]
518.3±50.0 °C(Predicted) | [density ]
1.401±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 12 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.2 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
9.42±0.10(Predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Description]
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 μM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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