ChemicalBook--->CAS DataBase List--->1698055-85-4

1698055-85-4

1698055-85-4 Structure

1698055-85-4 Structure
IdentificationBack Directory
[Name]

ARS-1620
[CAS]

1698055-85-4
[Synonyms]

CPD1588
ARS-1620
ARS-1620;ARS 1620;ARS1620
(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
2-Propen-1-one, 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-
1-?[4-?[(7S)?-?6-?Chloro-?8-?fluoro-?7-?(2-?fluoro-?6-?hydroxyphenyl)?-?4-?quinazolinyl]?-?1-?piperazinyl]?-?2-?propen-?1-?one
[Molecular Formula]

C21H17ClF2N4O2
[MDL Number]

MFCD31619312
[MOL File]

1698055-85-4.mol
[Molecular Weight]

430.84
Chemical PropertiesBack Directory
[Boiling point ]

614.7±55.0 °C(Predicted)
[density ]

1.434±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:70.0(Max Conc. mg/mL);162.47(Max Conc. mM)
[form ]

A solid
[pka]

6.03±0.35(Predicted)
[color ]

Off-white to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P280-P305+P351+P338
Hazard InformationBack Directory
[Uses]

ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
[Definition]

ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.
[storage]

Store at -20°C
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