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ChemicalBook--->CAS DataBase List--->172152-50-0

172152-50-0

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172152-50-0 Structure

172152-50-0 Structure
IdentificationBack Directory
[Name]

Ilaprazole sodium
[CAS]

172152-50-0
[Synonyms]

IY-81149 sodium
Ilaprazole sodium
Sodium ilaprazole
Ilaprazole sodium USP/EP/BP
[Molecular Formula]

C19H19N4NaO2S
[MDL Number]

MFCD30719460
[MOL File]

172152-50-0.mol
[Molecular Weight]

390.44
Chemical PropertiesBack Directory
[storage temp. ]

4°C, protect from light
[form ]

Solid
[color ]

White to off-white
[CAS DataBase Reference]

172152-50-0
Hazard InformationBack Directory
[Uses]

After oral administration, Ilaprazole sodium selectively enters the gastric parietal cells and is converted into an active metabolite of sulfenamide, which interacts with the sulfhydryl group on the H+/K+-ATPase to form a covalent combination of disulfide bonds, irreversibly inhibiting H+/K+- ATPase, which inhibits gastric acid secretion.
[in vitro]

On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC 50 of Ilaprazole (IY-81149) sodium is 9 nM.

[target]

TargetValue
Proton pump
()
H(+) /K(+)-ATPase
(in rabbit parietal cell preparation)		 6 μM
[storage]

4°C, protect from light
Spectrum DetailBack Directory
[Spectrum Detail]

Ilaprazole sodium(172152-50-0)1HNMR
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