172649-40-0

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172649-40-0 Structure

Identification	Back Directory
[Name] 3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE
[CAS] 172649-40-0
[Synonyms] ZD0947 AZD0947 AZD-0947 AZD 0947 ZD0947 >=98% (HPLC) (S)-3-(5-Oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl)benzonitrile 3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE Benzonitrile, 3-[(4S)-1,4,5,6,7,8-hexahydro-5-oxo-2-(trifluoromethyl)-4-quinolinyl]-
[Molecular Formula] C17H13F3N2O
[MDL Number] MFCD00944017
[MOL File] 172649-40-0.mol
[Molecular Weight] 318.29

Chemical Properties	Back Directory
[Boiling point ] 420.4±45.0 °C(Predicted)
[density ] 1.36±0.1 g/cm3(Predicted)
[storage temp. ] 2-8°C
[solubility ] DMSO: 2mg/mL, clear
[form ] powder
[pka] -0.32±0.60(Predicted)
[color ] white to beige
[optical activity] [α]/D -625 to -575°, c =0.5 in methanol

Hazard Information	Back Directory
[Uses] ZD0947 is an ATP-sensitive potassium channel activator with relatively effective activation of smooth muscle KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2). ZD0947 partially antagonizes pancreatic KATP channels (SUR1/Kir6.2) and cardiac KATP channels (SUR2A/Kir6.2). ZD0947 is potentially used to inhibit overactive bladder (OAB)[1].
[Biological Activity] ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2) but is a partial antagonist of pancreatic-type KATP channels (i.e. SUR1/Kir6.2) and cardiac-type KATP channels (i.e. SUR2A/Kir6.2). ZD0947 potently inhibits carbacho-induced contraction in the strips of human detrusor.
[References] [1] Effects of ZD0947, a novel and potent ATP-sensitive K+ channel opener, on smooth muscle-type ATP-sensitive K+ channels DOI:10.1016/j.ejphar.2016.09.038

172649-40-0 suppliers list

Company Name:	Alchem Pharmtech,Inc.
Tel:	8485655694
Website:	www.chemicalbook.com/ShowSupplierProductsList454175/0.htm

Company Name:	Amadis Chemical Company Limited
Tel:	571-89925085
Website:	http://www.amadischem.com

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