| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol.1 It inhibits rat liver mitochondrial and E. coli protein synthesis by 90.6 and 98.8%, respectively, when used at a concentration of 93 μM, and inhibits DNA synthesis in human lymphoblastoid cells by 83% at 1 mM. Bromamphenicol can also bind to the major adhesin subunit DraE from E. coli.2 | [References]
1. Manyan, D.R., Arimura, G.K., and Yunis, A.A. Comparative metabolic effects of chloramphenicol analogues Mol. Pharmacol. 11(5),520-527(1975).
2. Pettigrew, D.M., Roversi, P., Davies, S.G., et al. A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol Acta Crystallogr. D Biol. Crystallogr. 65(Pt 6),513-522(2009). |
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