| Identification | Back Directory | [Name]
4,5,6,7-TETRABROMOBENZOTRIAZOLE | [CAS]
17374-26-4 | [Synonyms]
TBB
TBBT
NSC 231634
CK2 INHIBITOR
TBB(NSC 231634)
TBB (enzyMe inhibitor)
4,5,6,7-Tetrabromotriazole
CASEIN KINASE II INHIBITOR I
4,5,6,7-TETRABROMOBENZOTRIAZOLE
CASEIN KINASE II INHIBITOR *TBB**
4,5,6,7-Tetrabromo-1H-benzotriazole
4,5,6,7-TETRABROMO-2-AZABENZIMIDAZOLE
1H-Benzotriazole, 4,5,6,7-tetrabroMo-
4,5,6,7-TetrabroMo-1H-benzo[d][1,2,3]triazole
4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt | [Molecular Formula]
C6HBr4N3 | [MDL Number]
MFCD06411399 | [MOL File]
17374-26-4.mol | [Molecular Weight]
434.71 |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
262-266°C | [Boiling point ]
552.5±45.0 °C(Predicted) | [density ]
2.840±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: 28 mg/mL
| [form ]
solid
| [pka]
3.87±0.40(Predicted) | [color ]
white
| [λmax]
300nm(MeOH)(lit.) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB,
with Ki values one to two orders of magnitude higher than that for CK2. | [Biological Activity]
A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. | [Biochem/physiol Actions]
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells. | [storage]
Store at -20°C |
|
|