| Identification | Back Directory | [Name]
REVERSIN 121 | [CAS]
174630-04-7 | [Synonyms]
REVERSIN 121
BOC-ASP(OBZL)-LYS(Z)-OTBU
L-Lysine, N-[(1,1-dimethylethoxy)carbonyl]-L-α-aspartyl-N6-[(phenylmethoxy)carbonyl]-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester | [Molecular Formula]
C34H47N3O9 | [MDL Number]
MFCD03788012 | [MOL File]
174630-04-7.mol | [Molecular Weight]
641.75 |
| Chemical Properties | Back Directory | [Boiling point ]
786.8±60.0 °C(Predicted) | [density ]
1.163±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO or ethanol: soluble | [form ]
powder | [pka]
10.75±0.46(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Description]
Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells. | [Uses]
Reversin 121 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium. | [General Description]
Reversin 121 is an analog of reversin and a dipeptide derivative. | [Biochem/physiol Actions]
Peptide chemosensitizer, inhibitor of P-glycoprotein. |
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