| Identification | Back Directory | [Name]
Pinealon | [CAS]
175175-23-2 | [Synonyms]
Pinealon
Peptides Lyophilized
Peptides Lyophilized Powder
L-Arginine, L-α-glutamyl-L-α-aspartyl- | [Molecular Formula]
C15H26N6O8 | [MOL File]
175175-23-2.mol | [Molecular Weight]
418.4 |
| Hazard Information | Back Directory | [Description]
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.
| [in vitro]
Pinealon (10, 50, 100 nM; 30 min) in a dose-dependent manner prevents an increase in the ROS accumulation induced by ouabain in cerebellar granule cells.
Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) suppresses the activation of ERK 1/2 in rat cerebellar granule cells exposed to 500 mM homo-cysteine (HC).
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