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1782-65-6

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1782-65-6 Structure

1782-65-6 Structure
IdentificationBack Directory
[Name]

(4aR)-5β-[2-(3-Furyl)ethyl]-3,4,4aβ,5,6,7,8,8a-octahydro-5,6α,8aα-trimethyl-1-naphthalenecarboxylic acid
[CAS]

1782-65-6
[Synonyms]

(-)-Hardwickiic acid
(4aR)-5β-[2-(3-Furyl)ethyl]-3,4,4aβ,5,6,7,8,8a-octahydro-5,6α,8aα-trimethyl-1-naphthalenecarboxylic acid
(4aR,5R,6R,8aR)-5-[2-(furan-3-yl)ethyl]-5,6,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalene-1-carboxylicaci
1-Naphthalenecarboxylic acid, 5-(2-(3-furanyl)ethyl)-3,4,4A,5,6,7,8,8A-octahydro-5,6,8A-trimethyl-, (4ar-(4aalpha,5alpha,6beta,8abeta))-
[Molecular Formula]

C20H28O3
[MDL Number]

MFCD17214876
[MOL File]

1782-65-6.mol
[Molecular Weight]

316.435
Chemical PropertiesBack Directory
[Melting point ]

106-107 °C
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity[1][2].
[References]

[1]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575.
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