| Identification | Back Directory | [Name]
XLR11 N-(4-hydroxypentyl) metabolite (CRM) | [CAS]
1782099-36-8 | [Synonyms]
4-Hydroxypentyl XLR11
XLR-11 4-hydroxypentyl metabolite
XLR11 N-(4-hydroxypentyl) metabolite
XLR11 N-(4-hydroxypentyl) metabolite RM
XLR11 N-(4-hydroxypentyl) metabolite (CRM)
[1-(5-fluoro-4-hydroxypentyl)indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone | [Molecular Formula]
C21H28FNO2 | [MOL File]
1782099-36-8.mol | [Molecular Weight]
345.45 |
| Hazard Information | Back Directory | [Description]
XLR11 is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB2 receptor over the central CB1 receptor.1 XLR11 also has an N-(5-fluoropentyl) chain, which increases binding to both CB receptors.2 XLR11 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of XLR11, based on the known metabolism of similar compounds.3,4 The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications. | [Uses]
4-Hydroxypentyl XLR11 is a metabolite of XLR11 (X746300), an aminoalkylindole compound that is expected to be a cannabinoid (CB) mimetic. | [Definition]
ChEBI: XLR11 N-(4-hydroxypentyl) metabolite is a member of indoles. | [References]
1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activity J. Med. Chem. 53(1),295-315(2010).
2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives US7241799B2,(2001).
3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
4. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010). |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|