| Identification | Back Directory | [Name]
Orphanin FQ (1-11) | [CAS]
178249-41-7 | [Synonyms]
Orphanin FQ (1-11)
L-Alanine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl- | [Molecular Formula]
C49H75N15O14 | [MDL Number]
MFCD11113679 | [MOL File]
178249-41-7.mol | [Molecular Weight]
1098.21 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 2 mg/ml in 20% acetonitrile / water | [form ]
Powder | [pka]
3.32±0.10(Predicted) | [color ]
White to off-white | [Sequence]
H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-OH |
| Hazard Information | Back Directory | [Uses]
Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice[1][2]. | [References]
[1] Reinscheid RK, et al. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem. 1996;271(24):14163-14168. DOI:10.1074/jbc.271.24.14163
[2] Rossi GC, et al. Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J Pharmacol Exp Ther. 1997;282(2):858-865. PMID:9262352 |
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