| Identification | Back Directory | [Name]
GNE-140 (racemate) | [CAS]
1802977-61-2 | [Synonyms]
GNE-140 (racemate)
GNE-140 racemate
(GNE 140 racemate
3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione
2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)- | [Molecular Formula]
C25H23ClN2O3S2 | [MOL File]
1802977-61-2.mol | [Molecular Weight]
499.04 |
| Chemical Properties | Back Directory | [Boiling point ]
739.0±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : ≥ 34 mg/mL (68.13 mM) | [form ]
Solid | [pka]
9.61±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor | [in vitro]
Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion. | [storage]
Store at -20°C |
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| Company Name: |
Wuxi AppTec
|
| Tel: |
022-59987777 13552403979 |
| Website: |
www.labnetwork.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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