| Identification | Back Directory | [Name]
2-(t-Butoxycarbonylamido)-1,3-bis (t-butoxycarbonylethoxy)propane | [CAS]
1807503-91-8 | [Synonyms]
AUN03918
C-NH-Boc-C-Bis-(C-PEG1-Boc)
2-(t-Butoxycarbonylamido)-1,3-bis (t-butoxycarbonylethoxy)propane
Propanoic acid, 3,3'-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl]bis(oxy)]bis-, 1,1'-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C22H41NO8 | [MDL Number]
MFCD28505566 | [MOL File]
1807503-91-8.mol | [Molecular Weight]
447.56 |
| Hazard Information | Back Directory | [Biological Activity]
C-NH-Boc-C-Bis-(C-PEG1-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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