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18133-22-7

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18133-22-7 Structure

18133-22-7 Structure
IdentificationBack Directory
[Name]

NETROPSIN DIHYDROCHLORIDE HYDRATE
[CAS]

18133-22-7
[Synonyms]

Nsc275885
netropsin2HClhydrate
Netropsin hydrate dihydrochloride
NETROPSIN DIHYDROCHLORIDE HYDRATE 96%
Netropsin, 2 HCl, Streptomycesnetropsis (1.24791)
1H-Pyrrole-2-carboxamide, 4-(aminoiminomethyl)aminoacetylamino-N-5-(3-amino-3-iminopropyl)aminocarbonyl-1-methyl-1H-pyrrol-3-yl-1-methyl-, dihydrochloride
[Molecular Formula]

C18H26N10O32HCl
[MDL Number]

MFCD00144883
[MOL File]

18133-22-7.mol
[Molecular Weight]

466.93
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble1mg/mL
[form ]

powder
[color ]

faint yellow
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

20/21/22
[Safety Statements ]

36/37
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
[RTECS ]

DW2973000
[HS Code ]

2941900000
Hazard InformationBack Directory
[Uses]

Netropsin Dihydrochloride is DNA minor groove binding ligand.
[Biochem/physiol Actions]

Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
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