| Identification | Back Directory | [Name]
Cortistatin-29 (rat) (trifluoroacetate salt) | [CAS]
1815618-17-7 | [Synonyms]
Cortistatin-29 (rat) (H-6444.0500)
Cortistatin-29 (rat) (trifluoroacetate salt) | [Molecular Formula]
C163H241F3N46O43S2 | [MOL File]
1815618-17-7.mol | [Molecular Weight]
3654.07 |
| Chemical Properties | Back Directory | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Water: 1 mg/ml | [form ]
A lyophilized powder | [Sequence]
Pyr-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bonds) |
| Hazard Information | Back Directory | [Description]
Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence. | [storage]
Store at -20°C |
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