| Identification | Back Directory | [Name]
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE | [CAS]
181629-93-6 | [Synonyms]
SB 228357
N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)- | [Molecular Formula]
C22H17F4N3O2 | [MDL Number]
MFCD00950378 | [MOL File]
181629-93-6.mol | [Molecular Weight]
431.38 |
| Chemical Properties | Back Directory | [Boiling point ]
625.4±55.0 °C(Predicted) | [density ]
1.398±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: ~8 mg/mL, soluble
| [form ]
solid
| [pka]
9.72±0.70(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS). | [Definition]
ChEBI: SB 228357 is an indolyl carboxylic acid. | [Biological Activity]
5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo . | [storage]
Store at RT |
|
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Energy Chemical
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http://www.energy-chemical.com |
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cjbscvictory
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13348960310 13348960310 |
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http://www.weikeqi-biotech.com/ |
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