| Identification | Back Directory | [Name]
2-Propenamide, 3-[2,3-dihydro-1-[(4-methoxyphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-hydroxy-, (2E)- | [CAS]
1817802-18-8 | [Synonyms]
MPT0B390
2-Propenamide, 3-[2,3-dihydro-1-[(4-methoxyphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-hydroxy-, (2E)- | [Molecular Formula]
C17H17N3O5S | [MOL File]
1817802-18-8.mol | [Molecular Weight]
375.4 |
| Chemical Properties | Back Directory | [density ]
1.452±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (665.96 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.49±0.23(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM[1]. | [References]
[1]. Han-Li Huang, et al. TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Theranostics. 2019 Sep 18;9(22):6676-6689. |
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