| Identification | Back Directory | [Name]
PD-1/PD-L1-IN1 | [CAS]
1818314-88-3 | [Synonyms]
PD-1/PD-L1-IN1
PD-1/PD-L1-IN1 BMS-1166
BMS-1166 (PD-1/PD-L1-IN1)
BMS-1166 (Synonyms: PD-1/PD-L1-IN1)
D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)- | [Molecular Formula]
C36H33ClN2O7 | [MDL Number]
MFCD31746874 | [MOL File]
1818314-88-3.mol | [Molecular Weight]
641.11 |
| Chemical Properties | Back Directory | [Boiling point ]
817.5±65.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | [form ]
A crystalline solid | [pka]
2.03±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
BMS-1166 is a novel and potent inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM. | [in vitro]
BMS-1166 had low toxicity to the tested cell lines and prevented the interaction of soluble PD-L1 with PD-1 receptors expressed on the cell surface. It attenuates the inhibitory effect of PD-L1 on T cell receptor-mediated T lymphocyte activation. | [target]
| Target | Value | PD-1/PD-L1 interaction
() | 1.4 nM |
| [storage]
Store at -20°C |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|