| Identification | Back Directory | [Name]
NAPHTHOL AS-E PHOSPHATE | [CAS]
18228-17-6 | [Synonyms]
NASEP
kg-501
KD-501
NAPHTHOL AS-E PHOSPHATE
2-naphthol-AS-E-phosphate
KG-501(NaphtholAS-Ephosphate)
NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE
NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY
2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE
3-hydroxy-2-(hydroxymethyl)-2-methyl-1-phenyl-1-propanone
N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide
N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide
2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-(phosphonooxy)-
[3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate
[3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501 | [EINECS(EC#)]
242-106-1 | [Molecular Formula]
C17H13ClNO5P | [MDL Number]
MFCD00042718 | [MOL File]
18228-17-6.mol | [Molecular Weight]
377.72 |
| Chemical Properties | Back Directory | [density ]
1.567±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO: soluble | [form ]
A crystalline solid | [pka]
1.04±0.30(Predicted) | [color ]
White to light yellow | [BRN ]
6664478 |
| Hazard Information | Back Directory | [Biological Activity]
Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM. | [in vitro]
Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons. | [in vivo]
Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex. | [target]
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Tags:18228-17-6
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