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1825345-33-2

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1825345-33-2 Structure

1825345-33-2 Structure
IdentificationBack Directory
[Name]

AZ9482
[CAS]

1825345-33-2
[Synonyms]

AZ9482
AZ 9482;AZ-9482
[Molecular Formula]

C26H22N6O2
[MDL Number]

MFCD32899873
[MOL File]

1825345-33-2.mol
[Molecular Weight]

450.49
Chemical PropertiesBack Directory
[density ]

1.34±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 0.25mg/mL,DMSO: 0.15mg/mL
[form ]

A crystalline solid
[pka]

12.09±0.40(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Description]

AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively). It induces centrosome declustering (EC50 = <18 nM) and a multipolar spindle phenotype in HeLa cells. AZ9482 inhibits the growth of OCI-LY19 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 3 nM).
Spectrum DetailBack Directory
[Spectrum Detail]

AZ9482(1825345-33-2)1HNMR
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