| Hazard Information | Back Directory | [Biological Activity]
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). | [in vitro]
Trastuzumab deruxtecan (1 pM-10 nM; 5 days) inhibits the growth of HER2‐positive KPL‐4 cells, with an IC 50 of 109.7 pM.
Trastuzumab deruxtecan (10 nM; 5 days) shows bystander killing effects in HER2‐negative MDA‐MB‐468 cells. | [in vivo]
Trastuzumab deruxtecan (3 mg/kg; a single iv) shows antitumor activity against not only HER2‐positive tumors but also HER2‐negative tumors under the co‐inoculated condition. | [storage]
Solution, -20°C, 2 years |
|
| Company Name: |
bioleaper
|
| Tel: |
18601717983 |
| Website: |
www.bioleaper.com/ |
|