| Identification | Back Directory | [Name]
3,4-O-Isopropylidene shikimic acid | [CAS]
183075-03-8 | [Synonyms]
4-O-Isopropylidene shikimic acid
3,4-O-Isopropylidene shikimic acid
3,4-O-Isopropylidene shikimic acid USP/EP/BP
7-Hydroxy-2,2-diMethyl-3a,6,7,7a-tetrahydrobenzo[d][1,3]dioxole-5-carboxylic acid
1,3-Benzodioxole-5-carboxylic acid, 3a,6,7,7a-tetrahydro-7-hydroxy-2,2-dimethyl-, (3aR,7R,7aS)- | [Molecular Formula]
C10H14O5 | [MDL Number]
MFCD17214943 | [MOL File]
183075-03-8.mol | [Molecular Weight]
214.22 |
| Hazard Information | Back Directory | [Description]
3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory effect which may be related to inhibiting the production of prostaglandin E2 and protecting free radical against oxidation.
3,4-Oxo-isopropylidene-shikimic acid has protective effects on experimental colitis induced by trinitrobenzenesulfonic acid in rats, probably due to an antioxidant action.
3. 3,4-Oxo-isopropylidene-shikimic acid has anti-thrombosis effect, it inhibits thrombosis by anti-platelet-aggregation.
4. 3,4-Oxo-isopropylidene shikimic acid relieves the brain edema of rats subjected to MCAT by improving the energy metabolism and Na +, K +-ATPase activity in rat brain tissue.
5. 3,4-Oxo-isopropylidene-shikimic acid can inhibit adhesion of polymorphonuclear leukocyte to TNF-alpha-induced endothelial cells in vitro.
6. 3,4-Oxo-isopropylidene-shikimic acid has analgesic and antioxidant activities, it exhibits moderate antioxidant activity by scavenging the superoxide radical and hydroxyl radical with IC50 values of 0.214 and 0.450 ug/mL, respectively.
7. 3,4-Oxo-isopropylidene-shikimic acid has exhibited ameliorative effect on cognitive impairment in experimental animal models of dementia, it can promote adipogenesis by up-regulating expressions of C/EBP β, PPAR γ, C/EBP α, aP2 and FAS, and also stimulate adipokines during adipocyte differentiation, suggests that stimulation of adipokines and cognitive enhancing effect of 3,4-oxo-isopropylidene-shikimic acid have some relationship. | [target]
NO | NOS | PGE | TNF-α | PPAR | Sodium Channel | ATPase | Potassium Channel |
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| Company Name: |
BioBioPha Co., Ltd.
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0871-65217109 13211707573; |
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http://www.biobiopha.com |
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