ChemicalBook--->CAS DataBase List--->183202-73-5

183202-73-5

183202-73-5 Structure

183202-73-5 Structure
IdentificationBack Directory
[Name]

KENDOMYCIN
[CAS]

183202-73-5
[Synonyms]

kendomycin from streptomyces violaceoruber
[Molecular Formula]

C29H42O6
[MDL Number]

MFCD00076711
[MOL File]

183202-73-5.mol
[Molecular Weight]

486.64
Chemical PropertiesBack Directory
[Melting point ]

236-240℃
[storage temp. ]

−20°C
[solubility ]

Soluble in DMSO
[form ]

solid
[color ]

Yellow
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM). It also acts as an endothelin receptor antagonist and has antiosteoporotic activities. Certain effects are thought to be mediated through inhibition of proteasomal degradation of proteins.
[Uses]

Kendomycin is an unusual macrocyclic metabolite containing a rare quinone methide group. Kendomycin is a potent antibacterial agent against Gram positive and Gram negative bacteria, including MRSA strains, also displaying antitumour activity. Kendomycin is a potent endothelin receptor agonist and demonstrates antiosteoporotic activity.
[Definition]

ChEBI: Kendomycin is a member of benzofurans.
[storage]

Store at -20°C
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