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1834571-04-8

1834571-04-8 Structure

1834571-04-8 Structure
IdentificationBack Directory
[Name]

Tat-NR2B9c TFA
[CAS]

1834571-04-8
[Synonyms]

NA-1 (TFA)
Tat-NR2B9c TFA
[Molecular Formula]

C?HF?O?
[MDL Number]

MFCD32690116
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

White to off-white
[Water Solubility ]

Water : ≥ 50 mg/mL (18.99 mM)
Hazard InformationBack Directory
[Description]

Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2]. EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1]p38[2]

[References]

[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.

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