| Identification | Back Directory | [Name]
AF12198 | [CAS]
185413-30-3 | [Synonyms]
AF12198
AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2
AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2
AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2 | [Molecular Formula]
C96H123N19O22 | [MDL Number]
MFCD02259571 | [MOL File]
185413-30-3.mol | [Molecular Weight]
1895.12 |
| Chemical Properties | Back Directory | [Melting point ]
>179°C (dec.) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Very Slightly) | [form ]
solid
| [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders. | [storage]
Store at -20°C |
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