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1870843-22-3

1870843-22-3 Structure

1870843-22-3 Structure
IdentificationBack Directory
[Name]

CCG224406)
[CAS]

1870843-22-3
[Synonyms]

CCG224406)
CCG-224406 (CCG 224406
[Molecular Formula]

C29H27FN6O5
[MOL File]

1870843-22-3.mol
[Molecular Weight]

558.56
Hazard InformationBack Directory
[Description]

CCG-22440 is a Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitor. CCG-224406 had an IC50 for GRK2 of 130 nM, greater than 700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1. G protein-coupled receptors (GPCRs) are central to many physiological processes. Regulation of this superfamily of receptors is controlled by GPCR kinases (GRKs), some of which have been implicated in heart failure.
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