| Identification | Back Directory | [Name]
pellitorine | [CAS]
18836-52-7 | [Synonyms]
pellitorine
2-dioxetane
trans-Pellitorine
isobutyl (E,E)-2,4-decadienamide
N-ISOBUTYL(E,E)-2,4-DECADIENAMIDE
(2E,4E)-N-Isobutyl-2,4-decadienamide
(2E,4E)-N-Isobutyldeca-2,4-dienamide
(2E,4E)-Decadienoic acid N-isobutylamide
N-ISOBUTYLDECA-TRANS-2-TRANS-4-DIENAMIDE
(E,E)-N-(2-Methylpropyl)-2,4-decadienamide
(2E,4E)-N-Isobutyldecadienamide (Pellitorine)
2,4-Decadienamide, N-(2-methylpropyl)-, (2E,4E)-
3-(2'-Spiroadamantane)-4-methoxy-4-(3''-phosphoryloxy)phenyl-1 | [Molecular Formula]
C14H25NO | [MOL File]
18836-52-7.mol | [Molecular Weight]
223.35 |
| Chemical Properties | Back Directory | [Melting point ]
88-89℃ | [Boiling point ]
368.7±15.0 °C(Predicted) | [density ]
0.882 | [FEMA ]
4148 | N-ISOBUTYLDECA-TRANS-2-TRANS-4-DIENAMIDE | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A crystalline solid | [pka]
14.74±0.46(Predicted) | [color ]
Yellow to beige | [Odor]
at 1.00 % in dipropylene glycol. spicy herbal | [Odor Type]
spicy | [JECFA Number]
1598 | [LogP]
3.92 |
| Hazard Information | Back Directory | [Uses]
Pellitorine is an ACAT (Acyl-CoA cholesteryl acyl transferase) and α-Glucosidase inhibitor. | [Definition]
ChEBI: A natural product found in Piper sarmentosum. | [Synthesis Reference(s)]
Synthetic Communications, 18, p. 77, 1988 DOI: 10.1080/00397918808057822
Tetrahedron Letters, 29, p. 3949, 1988 DOI: 10.1016/S0040-4039(00)80390-1 | [Biological Activity]
Pellitorine is an α-Glucosidase inhibitor isolated from the roots of Piper Nigrum th at exhibit anti-diabeticanti-canceranti-bacterial and anti-inflammatory properties. Pellitorine is an AC at (Acyl-CoA cholesteryl acyl transferase) inhibitor th at inhibits cholesterol esterification in HepG2 cells. Also pellitorine exhibit potent larvicide activity in mosquito by Inhibition of gene expression encoding V-type H+-ATPase and aquaporine 4. Some new research suggests th at anti-adipogenic activity of pellitorine depends on TRPV1. | [storage]
Store at -20°C |
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