| Identification | Back Directory | [Name]
METHYL TANSHINONATE | [CAS]
18887-19-9 | [Synonyms]
methyl (-)-(S)-tanshinonate
METHYL TANSHINONATE USP/EP/BP
6,7,8,9,10,11-Hexahydro-1,6-dimethyl-10,11-dioxophenanthro[1,2-b]furan-6-carboxylic acid methyl ester
(-)-6,7,8,9,10,11-Hexahydro-1,6-dimethyl-10,11-dioxophenanthro[1,2-b]furan-6-carboxylic acid methyl ester
Phenanthro[1,2-b]furan-6-carboxylic acid, 6,7,8,9,10,11-hexahydro-1,6-dimethyl-10,11-dioxo-, methyl ester, (6S)- | [Molecular Formula]
C20H18O5 | [MOL File]
18887-19-9.mol | [Molecular Weight]
338.35 |
| Chemical Properties | Back Directory | [Melting point ]
175-176 °C | [Boiling point ]
523.4±50.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [color ]
Red |
| Hazard Information | Back Directory | [Uses]
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 μM). Methyl tanshinonate can be used for diabetes and SARS-CoV research[1][2][3]. | [target]
Antifection | [References]
[1] Kim DH, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73. DOI:10.1016/j.cbi.2017.10.013
[2] Ni L, et al. Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS. J Pharm Biomed Anal. 2019 Jun 5;170:295-304. DOI:10.1016/j.jpba.2019.01.010
[3] Diniz LRL, et al. Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies. Biomolecules. 2021 Jan 7;11(1):74. DOI:10.3390/biom11010074 |
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