| Identification | Back Directory | [Name]
2H-Indazol-5-amine, 6-chloro-2-methyl- | [CAS]
1893125-36-4 | [Synonyms]
6-chloro-2-methyl-2H-indazol-5-amine
2H-Indazol-5-amine, 6-chloro-2-methyl- | [EINECS(EC#)]
200-001-0 | [Molecular Formula]
C8H8ClN3 | [MOL File]
1893125-36-4.mol | [Molecular Weight]
181.62 |
| Chemical Properties | Back Directory | [Boiling point ]
365.6±22.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [pka]
2.05±0.10(Predicted) | [InChI]
InChI=1S/C8H8ClN3/c1-12-4-5-2-7(10)6(9)3-8(5)11-12/h2-4H,10H2,1H3 | [InChIKey]
YRZNRFJEBAPCCO-UHFFFAOYSA-N | [SMILES]
N1=C2C(C=C(N)C(Cl)=C2)=CN1C |
| Hazard Information | Back Directory | [Synthesis]
A suspension of 6-Chloro-1-methyl-5-nitro-1H-indazole (700 mg, 3.31 mmol), NH4CI (1 .59g, 29.77mmol) & Fe powder (1.66g, 29.77mmol) in a mixture of EtOH: Water (15mL: 15mL) was heated to 80°C for 6h. After 6h, TLC analysis indicated the formation of a polar spot (Ninhydrin positive). Then, the reaction mixture was cooled to RT and filtered through the celite bed; the celite bed was washed with EtOH (50mL); the filtrate was concentrated under reduced pressure to give a crude product. The crude product was purified by column chromatography (silica gel 100-200mesh) using 25% EtOAc in petroleum ether as an eluent to give 6- chloro-2-methyl-2H-indazol-5-amine (quantitative yield) as an off-white solid.
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