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1904651-39-3

1904651-39-3 Structure

1904651-39-3 Structure
IdentificationBack Directory
[Name]

Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-
[CAS]

1904651-39-3
[Synonyms]

7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-1,2,3,4-tetrahydroquinoline
7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline
Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-
7-(dif luoromethyl)-6-(1 -methyl-1 H-pyrazol-4-y1)-1,2,3,4-tetrahydroquinoline
[Molecular Formula]

C14H15F2N3
[MOL File]

1904651-39-3.mol
[Molecular Weight]

263.29
Chemical PropertiesBack Directory
[solubility ]

Dichloromethane; Ethyl Acetate; Methanol
[form ]

Solid
[color ]

Off-White
Hazard InformationBack Directory
[Uses]

7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-1,2,3,4-tetrahydroquinoline is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.
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