ChemicalBook--->CAS DataBase List--->1908414-82-3

1908414-82-3

1908414-82-3 Structure

1908414-82-3 Structure
IdentificationBack Directory
[Name]

LMPTP inhibitor1
[CAS]

1908414-82-3
[Synonyms]

CS-2789
MDK4823
MDK-4823
MDK 4823
LMPTP-IN23
LMPTP-IN-23
LMPTP-IN 23
INVIVO-4823
LMPTP inhibitor1
MLS-0322825 Cmpd 23
LMW-PTP Inhibitor I
LMPTP INHIBITOR COMPOUND 1
LMPTP inhibitor-Compound 23
NN-Diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]benzamide
[Molecular Formula]

C28H36N4O
[MOL File]

1908414-82-3.mol
[Molecular Weight]

444.61
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 20mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,PBS (pH 7.2): 3mg/mL
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

LMW-PTP inhibitor I is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC50 = 0.8 μM). It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 μM. LMW-PTP inhibitor I increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 μM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day.
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