| Identification | Back Directory | [Name]
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE | [CAS]
191219-80-4 | [Synonyms]
YM 976
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl- | [Molecular Formula]
C17H16ClN3O | [MDL Number]
MFCD04113219 | [MOL File]
191219-80-4.mol | [Molecular Weight]
313.78 |
| Chemical Properties | Back Directory | [Melting point ]
132.7-134.0 °C(lit.) | [Boiling point ]
485.4±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: 16 mg/mL | [form ]
solid | [pka]
2.11±0.20(Predicted) | [color ]
pale yellow |
| Hazard Information | Back Directory | [Uses]
YM 976 is an inhibitor of PDE4. | [Definition]
ChEBI: 4-(3-chlorophenyl)-1,7-diethyl-2-pyrido[2,3-d]pyrimidinone is a member of pyrimidines. | [Biological Activity]
Orally active PDE4 inhibitor (IC 50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration. |
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