| Identification | Back Directory | [Name]
HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE | [CAS]
19179-12-5 | [Synonyms]
cyclo(glycylprolyl)
HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
octahydropyrrolo[1,2-a]piperazine-1,4-dione
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-
(Pro-Gly).Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro- (6CI,7CI,8CI,9CI) | [Molecular Formula]
C7H10N2O2 | [MDL Number]
MFCD01083707 | [MOL File]
19179-12-5.mol | [Molecular Weight]
154.17 |
| Chemical Properties | Back Directory | [Boiling point ]
447.9±34.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.21±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione), an alkaloid isolated from green algae Ulva prolifera, possesses antialgal activity against the common harmful red tide microalgae[1]. Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione) possesses antiamnesic effects and neuroprotective actions[2]. | [Definition]
ChEBI: Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid. | [in vivo]
Cyclo-(Pro-Gly) (0.1 and 10 mg/kg, ip ) seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation[3]. | [References]
[1] Ying-ying Sun, et al. Isolation, Purification, and Identification of Antialgal Substances in Green Alga Ulva Prolifera for Antialgal Activity Against the Common Harmful Red Tide Microalgae. Environ Sci Pollut Res Int. 2016 Jan;23(2):1449-59. DOI:10.1007/s11356-015-5377-7
[2] Fumitaka Hayasaka, et al. Production Method for Cyclic Dipeptide Derived from Native Collagen. Food Science and Technology Research, 22 (4), 477-483, 2016.
[3] T A Gudasheva, et al. Identification of a Novel Endogenous Memory Facilitating Cyclic Dipeptide Cyclo-Prolylglycine in Rat Brain. FEBS Lett. 1996 Aug 5;391(1-2):149-52. DOI:10.1016/0014-5793(96)00722-3 |
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