192203-60-4

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192203-60-4 Structure

Identification	Back Directory
[Name] N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid
[CAS] 192203-60-4
[Synonyms] CPG2 Inhibitor Carboxypeptidase G2 Inhibitor N-[[(4-methoxyphenyl)thio]carbonyl]- Carboxypeptidase G2 (CPG2) Inhibitor N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid L-GlutaMic acid, N-[[(4-Methoxyphenyl)thio]carbonyl]- N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid USP/EP/BP (2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioicaci CPG2 INHIBITOR;L-GLUTAMIC ACID; N-[[(4-METHOXYPHENYL)THIO]CARBONYL]-
[Molecular Formula] C13H15NO6S
[MDL Number] MFCD16039212
[MOL File] 192203-60-4.mol
[Molecular Weight] 313.33

Chemical Properties	Back Directory
[density ] 1.43
[storage temp. ] Store at -20°C
[solubility ] H2O : 1.43 mg/mL (4.56 mM; Need ultrasonic)
[form ] Powder
[pka] 3.41±0.10(Predicted)
[color ] White to off-white

Hazard Information	Back Directory
[Uses] Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.
[References] [1] Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956. DOI:10.1021/jm990004i [2] Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. DOI:10.1158/1078-0432.CCR-07-4800 [3] Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55. DOI:10.1158/0008-5472.CAN-07-0297 [4] Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8. DOI:10.1158/0008-5472.CAN-05-0393

Spectrum Detail	Back Directory
[Spectrum Detail] N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid(192203-60-4)¹HNMR

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