| Identification | Back Directory | [Name]
(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID | [CAS]
193146-63-3 | [Synonyms]
(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID | [Molecular Formula]
C45H85NO6SSi3 | [MDL Number]
MFCD04039706 | [MOL File]
193146-63-3.mol | [Molecular Weight]
852.481 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Sticky Foam | [Boiling point ]
761.2±60.0 °C(Predicted) | [density ]
0.979±0.06 g/cm3(Predicted) | [solubility ]
Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate | [form ]
Foam | [pka]
4.05±0.10(Predicted) | [color ]
Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Sticky Foam | [Uses]
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-
resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arr
ests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
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