| Identification | Back Directory | [Name]
Apoptolidin | [CAS]
194874-06-1 | [Synonyms]
FU 40A
Apoptolidin
Apoptolidin A Ready Made Solution | [EINECS(EC#)]
200-664-3 | [Molecular Formula]
C58H96O21 | [MDL Number]
MFCD09752711 | [MOL File]
194874-06-1.mol | [Molecular Weight]
1129.38 |
| Chemical Properties | Back Directory | [Melting point ]
128-130° | [alpha ]
21D -5.2° (c = 1.0 in methanol) | [Fp ]
87℃ | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DMF, ethanol, or methanol. | [form ]
DMSO solution | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol or methanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1?Is believed to act via inhibition of F0F1-ATPase2?but correlation studies indicate that a second mechanism may be the actual mode of action3.? Cell permeable. | [Uses]
Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action. | [References]
1) Kim et al. (1997), Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.; J. Antibiot. (Tokyo), 50 628
2) Salomon et al. (2001), Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase; Chem. Biol., 8 71
3) Wender et al. (2006), Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues; Org. Lett., 8 589 |
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