ChemicalBook--->CAS DataBase List--->1951431-22-3

1951431-22-3

1951431-22-3 Structure

1951431-22-3 Structure
IdentificationBack Directory
[Name]

BKI-1369
[CAS]

1951431-22-3
[Synonyms]

BKI-1369
BKI1369,BKI 1369
[Molecular Formula]

C23H27N7O
[MDL Number]

MFCD32197194
[MOL File]

1951431-22-3.mol
[Molecular Weight]

417.51
Chemical PropertiesBack Directory
[Boiling point ]

626.8±50.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 50 mg/mL (119.76 mM)
[form ]

Solid
[pka]

9.02±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves[1]. IC50: 1.52 μM (hERG)[1]

[References]

[1]. Lee S, et al. Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis. Antimicrob Agents Chemother. 2018 Jun 26;62(7).

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