ChemicalBook--->CAS DataBase List--->1973383-30-0

1973383-30-0

1973383-30-0 Structure

1973383-30-0 Structure
IdentificationBack Directory
[Name]

Propargyl-PEG6-Br
[CAS]

1973383-30-0
[Synonyms]

Propargyl-PEG6-Br
Propargyl-PEG6-bromide
1-bromo-3,6,9,12,15,18-hexaoxahenicos-20-yne
[Molecular Formula]

C15H27BrO6
[MDL Number]

MFCD32263749
[MOL File]

1973383-30-0.mol
[Molecular Weight]

383.28
Hazard InformationBack Directory
[Biological Activity]

Propargyl-PEG6-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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