| Identification | Back Directory | [Name]
Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- | [CAS]
1973408-76-2 | [Synonyms]
ABM-14
4-[3-[4-(4-hydroxyphenyl)phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- | [Molecular Formula]
C25H18F3N3O2S | [MOL File]
1973408-76-2.mol | [Molecular Weight]
481.49 |
| Chemical Properties | Back Directory | [Boiling point ]
620.0±65.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.60±0.26(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 to degrade AR[1]. | [References]
[1]. Meizhong Jin, et al. Compounds and methods for the targeted degradation of the androgen receptor. WO2016118666A1. |
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csynbio
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