| Identification | Back Directory | [Name]
(+/-)-LY367385 | [CAS]
198419-90-8 | [Synonyms]
LY 367385, (±)-
4-(AMINO-CARBOXY-METHYL)-3-METHYL-BENZOIC ACID
BENZENEACETIC ACID, A-AMINO-4-CARBOXY-2-METHYL- | [Molecular Formula]
C10H11NO4 | [MDL Number]
MFCD10565942 | [MOL File]
198419-90-8.mol | [Molecular Weight]
209.2 |
| Chemical Properties | Back Directory | [Boiling point ]
434.0±45.0 °C(Predicted) | [density ]
1.393±0.06 g/cm3(Predicted) | [solubility ]
Water: 20 mg/ml | [form ]
A solid | [pka]
1.72±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
(±)-LY367385 is an antagonist of metabotropic glutamate receptor 1α (mGluR1α).1 It inhibits phosphoinositide (PI) hydrolysis selectively in AV-12 cells expressing mGluR1α over those expressing mGluR5a (IC50s = 19 and >300 μM, respectively). | [References]
1. Salt, T.E., Jones, H.E., Copeland, C.S., et al. Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus Neuropharmacology 79(100),405-411(2014). |
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