| Identification | Back Directory | [Name]
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide | [CAS]
199433-58-4 | [Synonyms]
Y 33075
Y33075;Y 39983
Y 39983;Y39983
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide
Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide ISO 9001：2015 REACH | [Molecular Formula]
C16H16N4O | [MDL Number]
MFCD16038858 | [MOL File]
199433-58-4.mol | [Molecular Weight]
280.32 |
| Chemical Properties | Back Directory | [Boiling point ]
588.8±50.0 °C(Predicted) | [density ]
1.32 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (178.37 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
11.13±0.20(Predicted) |
| Hazard Information | Back Directory | [Definition]
ChEBI: 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide is a pyrrolopyridine. | [Biological Activity]
Y-33075 is a potent ROCK inhibitor derived from Y-27632, but more active with IC50 value of 3.6 nM. | [in vitro]
Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC 50 of 3.6 nM. It also inhibits PKC and CaMKII more potently than Y-27632, and the IC 50 s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC 50 s of Y-27632 and Y- 33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC 50 s of Y-27632 and Y-33075 for PKC are 82 and 117 times those for ROCK, respectively, whereas the IC 50 s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983. It (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca 2+ -free solutions. Y-33075 ( 10 μM) shows no effect on the [Ca 2+ ]i increase with the high-potassium (high-K) solution. p> | [target]
| ROCK 3.6 nM (IC 50 ) | PKC 420 nM (IC 50 ) | CaMKII 810 nM (IC 50 ) | |
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Musechem
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Twochem Co.Ltd.
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DC Chemicals
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