| Identification | Back Directory | [Name]
MFCD00167693 | [CAS]
199735-88-1 | [Synonyms]
HY-107999
MFCD00167693
3-{[(3,4-dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 3-[[(3,4-dichlorophenyl)amino]carbonyl]- | [Molecular Formula]
C15H13Cl2NO3 | [MDL Number]
MFCD00167693 | [MOL File]
199735-88-1.mol | [Molecular Weight]
326.17 |
| Chemical Properties | Back Directory | [Boiling point ]
569.1±50.0 °C(Predicted) | [density ]
1.529±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO:157.5(Max Conc. mg/mL);482.87(Max Conc. mM)
Ethanol:65.0(Max Conc. mg/mL);199.28(Max Conc. mM) | [form ]
A solid | [pka]
4.19±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA. | [Biological Activity]
CADD522 is a cell-permeable, bioavailable, non-toxic carbamoyl-bicycloheptene-carboxylate th at inhibits RUNX2-DNA binding, thereby increases RUNX2 stability, upregulates RUNX2 expression levels and downregulates RUNX2 responsive genes transcription. CADD522 inhibits mitochondrial oxidative phosphorylation by decreasing the mitochondrial oxygen consumption rate and ATP production in human breast cancer cells in a RUNX2-independent manner. CADD-522 suppresses in vivo tumor growth and metastasis, and appreciably prolongs the survival rates without the need for surgery or chemotherapy. |
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| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Atomic chemistry
|
| Tel: |
0370-2785705 17550096163 |
| Website: |
www.yuanzichem.com |
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