| Identification | Back Directory | [Name]
Benzoic acid, 5-hydroxy-2-methyl-4-nitro- (9CI) | [CAS]
199929-14-1 | [Synonyms]
5-hydroxy-2-methyl-4-nitrobenzoic acid
Benzoic acid, 5-hydroxy-2-methyl-4-nitro-
Benzoic acid, 5-hydroxy-2-methyl-4-nitro- (9CI) | [Molecular Formula]
C8H7NO5 | [MOL File]
199929-14-1.mol | [Molecular Weight]
197.14 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow solid | [Synthesis]
A solution of 5-hydroxy-2-methylbenzoic acid( 5.00 g, 32.9 mmol, 1.0 eq) in H2SO4 (50 mL, 98% purity) was cooled to 0 °C and to this mixture was added KNO3 (3.49 g, 34.5 mmol, 1.1 eq) at 0 °C. The mixture was stirred at 20 °C for 1 h. TLC indicated that the starting material was completely consumed, and a main spot was detected. The mixture was treated with ice water (40 mL) slowly and extracted with DCM(20 mL x 5). The combined organic layers were dried over NazSC，filtered, and concentrated under vacuum to give a residue which was purified by flash silica gel chromatography. Benzoic acid, 5-hydroxy-2-methyl-4-nitro- (9CI) (640 mg, 3.25 mmol, 10% yield) was obtained after purification.
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