| Identification | Back Directory | [Name]
GEN6776 | [CAS]
2009273-71-4 | [Synonyms]
CS-2823
GEN6776
GNE-6776
GEN6776 GNE-6776
6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-[3,3'-bipyridine]-6-carboxamide
[3,3'-Bipyridine]-6-carboxamide, 6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-
5-[6-Amino-4-ethyl-5-(4-hydroxyphenyl)pyridin-3-yl]-N-methylpyridine-2-carboxamide | [Molecular Formula]
C20H20N4O2 | [MDL Number]
MFCD31657364 | [MOL File]
2009273-71-4.mol | [Molecular Weight]
348.4 |
| Chemical Properties | Back Directory | [Boiling point ]
609.7±55.0 °C(Predicted) | [density ]
1.242±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 310 mg/mL (889.78 mM) | [form ]
Solid | [pka]
8.14±0.15(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GNE6776, is a selective USP7 inhibitor. | [in vivo]
GNE-6776 (100 or 200 mg/kg; oral gavage on a once or twice daily schedule; for 10 days) inhibits EOL-1 xenograft growth in mice[1]. | Animal Model: | Immunodeficient C.B-17 SCID mice (aged 12-16 weeks) with EOL1 AML xenograft[1] | | Dosage: | 100 or 200?mg/kg | | Administration: | Oral gavage on a once or twice daily schedule; for 10 days | | Result: | Significant EOL-1 xenograft growth inhibition. |
| [storage]
Store at -20°C |
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