| Identification | Back Directory | [Name]
meclocycline | [CAS]
2013-58-3 | [Synonyms]
GS-2989
NSC-78502
Aids043973
Aids-043973
MECLOCYLINE
meclocycline
Meclocycline base
Meclocycline(usan)
Chlormethylenecycline
meclocycline USP/EP/BP
GGQJXCQBBONZFX-IWVLMIASSA-N
Meclocycline (1.0mg/ml in DMSO)
7-Chloro-6-Methylene-oxytetracycline, GS 2989, NCS 78502
(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,5β,10,12,12aβ-pentahydroxy-6-methylene-7-chloro-1,11-dioxo-2-naphthacenecarboxamide
(4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, (4S,4aR,5S,5aR,12aS)-
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,5,10,12,12A-pentahydroxy-6-methylene-1,11-dioxo-, [4S-(4.alpha.,4A.alpha.,5.alpha.,5A.alpha.,12A.alpha.)]- (9ci) | [EINECS(EC#)]
217-938-3 | [Molecular Formula]
C22H21ClN2O8 | [MDL Number]
MFCD00864872 | [MOL File]
2013-58-3.mol | [Molecular Weight]
476.86 |
| Chemical Properties | Back Directory | [Melting point ]
>167°C (dec.) | [Boiling point ]
837.0±65.0 °C(Predicted) | [density ]
1.72±0.1 g/cm3(Predicted) | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
Yellow to Dark Yellow | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
Meclocycline is a close structural analogue of methacycline which shows antibacterial and antiprotozoan activity. | [Uses]
Meclocycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of chlortetracycline to yield an exocyclic 6-methylene. Meclocyline is a close structural analogue of methacycline. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Meclocycline has been extensively cited in the literature with over 400 references. | [Definition]
ChEBI: Meclocycline is a member of tetracyclines. | [Brand name]
Meclan (Johnson & Johnson). |
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